1. Your resume is poorly written or organized. Your resume is a reflection of you, and the best work you can produce. If it is littered with spelling errors, has pasted job descriptions out of the job postings for your previous jobs, or the sentences don't make sense - it makes you seem careless at best, incompetent at worst. Have multiple people review your resume before you send it out, and make sure it is something on which you are proud to have your name.
2. You don't seem like you are interested in the job. This could mean you send a cover letter or a resume geared towards a different job, you are difficult to reach, or you aren't able to communicate why you want the job in the interview. I want to work with people who want to stick around, and are excited about what we do. State clearly at some point that you want the job, and why you want it. That means you should do your homework on the company and the position ahead of time, and have a good idea of what the job is. Bonus points if you follow up with the interviewers to thank them for the interview- about 10% of people seem to do this anymore, and it certainly displays interest.
3. You come off as unprofessional. For me this is strongly tied to "you don't seem like you are interested in the job". Unprofessional behavior can be a sign of lack of maturity or competence- and can range from lack of personal hygiene, to being late for the interview, to being rude to the admin staff before or after the interview. One time, there was a phone interviewee who sounded like they were going for a walk through the park (wind, huffing and puffing up stairs), and then banging around pots and pans. Take the time to make sure find a quiet space for phone or video interviews, and make sure you research or ask about expectations for dress for the interview if you are unsure.
5. The specific gap on the team isn't the right one for you right now. Newly hired engineers are almost always brought onto a team. This part is out of your control, and is just about timing. Sometimes we've lost our most experienced team member, and need somebody with direct experience to be able to jump onto the team, mentor others, and keep up with the workload. Sometimes we have a pretty well rounded team and can afford to take somebody with little to no applicable experience, to be mentored and build up longer term organizational experience. This all to say - just because you don't get a job doesn't necessarily mean you should never apply to the company again. Now, if you bombed the interview, and showed up 30 minutes late and hadn't showered in a week - you may want to wait until people forget that impression of you or the management turns over. But otherwise, you can apply to similar postings, and see if another one is a better fit for you.
Ultimately- keep trying, and keep putting your best foot forward! Good luck out there!
-Vanessa